
Travis L. Bullock 1, Erica J. Traxel 1, Jay S. Belani1,
David G. Bostwick 2, Peter A. Humphrey 3, Gerald L. Andriole1
1 Division of Urology, Washington University School of Medicine, St. Louis, MO
2 Bostwick Laboratories, Richmond, VA
3 Department of Pathology, Washington University School of Medicine, St. Louis, MO
Introduction:The Envisioneering TargetScan® is a novel transrectal ultrasound (TRUS) device that uses a flexible needle to biopsy the prostate in a template fashion. Firsta computer algorithm identifies an ideal biopsy scheme using the measured dimensions of the prostate. The system then uses a fixed template that allows the physician to biopsy the prostate at specific locations and to target the same region of the prostate in the future if needed.
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We simulated the TargetScan® biopsy on 20 men who underwent radical prostatectomy for localized prostate cancer. The height, longitudinal length and transverse width of the specimen were measured. Using these dimensions, a computerized algorithm generated specific coordinates at which to biopsy the specimen. The specimen was then placed in the model and 12 cores were taken from the gland based on the template. In 14 specimens two separate surgeons biopsied the prostate at the same coordinates, for a total of 24 cores per gland. All TargetScan® biopsy specimens were sent to one pathologist (DGB) for review. The whole prostate specimen was step-sectioned to identify the locations of the cancer. The preoperative clinical biopsy data, TargetScan® biopsy data and final pathology data were compared. A Mann-Whitney rank sum test was used to compare the differences between two groups.
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